PDRN What is it?

Ingredients

Water, Glycerin, Niacinamide, 1,2-Hexanediol, Sodium Hyaluronate, , Salmon DNA (5,000ppm), Palmitoyl Tripeptide-5, Caprylyl Glycol, Adenosine, Hydrolyzed Collagen, Dextrin, sh-Oligopeptide-9, sh-Oligopeptide-1, sh-Polypeptide-3,
sh-polypeptide-1, sh-Oligopeptide-2, Galloyl Pentapeptide-33, Ethylhexylglycerin, sh-Polypeptide-9, Copper Tripeptide-1, sh-Polypeptide-22, Pentapeptide-19, Octapeptide-7, sh-Decapeptide-7, sh-Octapeptide-4.

Hyaluronic Acid (HA)

Hyaluronic Acid (HA) is a naturally occurring substance in the human body, primarily found in the skin, connective tissues, and eyes. It plays a crucial role in retaining moisture, keeping tissues hydrated and lubricated.

The Protocol

• Topical use – Spread and appropriate amount over the skin until its absorbed, to speed and improve absorption into the skin simply apply plastic cling wrap to face. (1-3 times / week apply after face is cleaned)
• Micro needling Roller – Apply generously across areas that are to be treated use the roller once applies across the area.
• Micro needling Pen – Similar to the roller protocol.

Article Feature in Allure.com

December 12, 2024

For 2025, industry experts predict expansions on already booming product and treatment themes within the skin-care space. You can expect to see souped-up sunscreens, body serums as powerful as those for your face, and lots of multitasking products. You will also likely notice buzzy in-office treatments, like the “salmon sperm facial,” influencing what you see on shelves.

Dermatologists have long warned us that more isn’t necessarily better in skin care. Besides the potential irritation that can go with using too many actives (or trying too many TikTok trends) at once, layering the wrong combo of products can inactivate skin-care ingredients, therefore rendering a product ineffective. “For this reason, simplified routines work well,” says Dr. Garshick. “Not only is it easier to be consistent, but it’s also less likely to disrupt the skin barrier.”

For brands, the desire for simplicity often translates into multitasking products that deliver results. Dr. Garshick points to a product like the Colorescience Total Eye 3-in-1 Renewal Therapy SPF 35, which acts as a wrinkle-smoothing, SPF-infused eye cream and a concealer. “This eye cream brightens, hydrates and uses antioxidants and hyaluronic acid while also protecting the skin from UV radiation,” she says. “Additionally, the use of peptides helps to improve firmness and the overall appearance of fine lines and wrinkles.”

Multitasking products with multi benefits might also see growth amid impending economic changes. Depending on what new tariff policies are imposed under the incoming Trump administration, economic experts predict consumers could see significant price increases (according to recent Allure reporting, anywhere from 10-60%) on beauty and personal-care products from imported brands and those made in the US. That may influence some consumers to purchase one product that can do multiple jobs (say, a mask that can work as a moisturizer or a moisturizer that doubles as a makeup primer) or deliver multiple benefits at a lower price, rather than several individual products that will add up to a bigger bill. This may even lead a consumer to ask their dermatologist what products they can cut from their routine.

Clinical Studies

The Combination of Niacinamide, Vitamin C, and PDRN Mitigates Melanogenesis by Modulating Nicotinamide Nucleotide Transhydrogenase

1. Maylin Anti-Aging Center Apgujeong, Seoul 06005, Korea
2. Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Korea
3. Functional Cellular Networks Laboratory, Graduate School and Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon 21999, Korea
4. I’ll Global Co., Inc., Seoul 06532, Korea
5. Department of Thoracic and Cardiovascular Surgery, Gil Medical Center, Gachon University, Incheon 21565, Korea

* Authors to whom correspondence should be addressed.

^†These authors contributed equally to this work.

Conclusion

PDRN represents a promising advancement in regenerative medicine and skincare, offering a range of therapeutic benefits. As research continues, its applications are expected to expand, providing new avenues for treatment in various medical and cosmetic fields. Various brands may depict their products to be better than the other but it all boils down to the composition of the product.